Argonaute and RNA--getting into the groove

Song, J. J., Joshua-Tor, L. (February 2006) Argonaute and RNA--getting into the groove. Curr Opin Struct Biol, 16 (1). pp. 5-11. ISSN 0959-440X (Print)

Abstract

RNAi has made an enormous impact on biology in a very short period of time. It became an extraordinarily useful and simple tool for gene silencing, even as its fascinating mechanism was gradually unraveling. Understanding the mechanism of RNAi-related pathways, including both transcriptional and posttranscriptional gene silencing and even processes such as DNA elimination in Tetrahymena, have benefited from an incredible marriage of genetics, biochemistry, molecular biology, bioinformatics and finally structural biology. Structural biology played a key role in deciphering the role that a central player--the Argonaute protein--has in all RNAi processes.

Item Type:	Paper
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription bioinformatics > genomics and proteomics > design > nucleic acid design > RNAI Design bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > argonaute proteins bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression > post transcriptional modification structural biology
CSHL Authors:	Joshua-Tor, Leemor Song, Ji-Joon
Communities:	CSHL labs > Joshua-Tor lab School of Biological Sciences > Publications
Depositing User:	CSHL Librarian
Date:	February 2006
Date Deposited:	08 Dec 2011 16:14
Last Modified:	26 Sep 2014 15:45
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/22905

Actions (login required)

Administrator's edit/view item