RNA-induced initiation of transcriptional silencing (RITS) complex structure and function

Bhattacharjee, S., Roche, B., Martienssen, R. A. (June 2019) RNA-induced initiation of transcriptional silencing (RITS) complex structure and function. RNA Biol, 16 (9). pp. 1133-1146. ISSN 1547-6286

URL: https://www.ncbi.nlm.nih.gov/pubmed/31213126
DOI: 10.1080/15476286.2019.1621624

Abstract

Heterochromatic regions of the genome are epigenetically regulated to maintain a heritable '"silent state"'. In fission yeast and other organisms, epigenetic silencing is guided by nascent transcripts, which are targeted by the RNA interference pathway. The key effector complex of the RNA interference pathway consists of small interfering RNA molecules (siRNAs) associated with Argonaute, assembled into the RNA-induced transcriptional silencing (RITS) complex. This review focuses on our current understanding of how RITS promotes heterochromatin formation, and in particular on the role of Argonaute-containing complexes in many other functions such as quelling, release of RNA polymerases, cellular quiescence and genome defense.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dicer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > dicer

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene silencing
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matthew Dunn
Date: 18 June 2019
Date Deposited: 22 Jul 2019 18:14
Last Modified: 03 Sep 2019 20:49
Related URLs:
URI: http://repository.cshl.edu/id/eprint/38163

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