Proliferation, Senescence, and Neoplastic Progression of Beta-Cells in Hyperplasic Pancreatic-Islets

Teitelman, G., Alpert, S., Hanahan, D. (January 1988) Proliferation, Senescence, and Neoplastic Progression of Beta-Cells in Hyperplasic Pancreatic-Islets. Cell, 52 (1). pp. 97-105. ISSN 0092-8674

URL: http://www.ncbi.nlm.nih.gov/pubmed/2894250
DOI: 10.1016/0092-8674(88)90534-X

Abstract

Three different cases of pancreatic beta cell hyperplasia in mice are accompanied by an increase in a subclass of cells expressing tyrosine hydroxylase (TH), a neuronal enzyme. In the nontumorigenic cases of islet growth during normal pregnancy and in the obese mutant mouse, the TH-insulin cells do not divide, in contrast to the "insulin-only" cells. In later stages the number of proliferating insulin-only cells decreases concomitant with an increase in the number of nondividing TH-insulin cells, suggesting that the TH-insulin cells are on a pathway to senescence. In the presence of an oncoprotein the TH-insulin cells are able to proliferate. The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell proliferation
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
organism description > animal > mammal > rodent > mouse
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: 15 January 1988
Date Deposited: 29 Sep 2017 14:44
Last Modified: 29 Sep 2017 14:46
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35222

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