Teitelman, G., Alpert, S., Hanahan, D. (January 1988) Proliferation, Senescence, and Neoplastic Progression of Beta-Cells in Hyperplasic Pancreatic-Islets. Cell, 52 (1). pp. 97-105. ISSN 0092-8674
Abstract
Three different cases of pancreatic beta cell hyperplasia in mice are accompanied by an increase in a subclass of cells expressing tyrosine hydroxylase (TH), a neuronal enzyme. In the nontumorigenic cases of islet growth during normal pregnancy and in the obese mutant mouse, the TH-insulin cells do not divide, in contrast to the "insulin-only" cells. In later stages the number of proliferating insulin-only cells decreases concomitant with an increase in the number of nondividing TH-insulin cells, suggesting that the TH-insulin cells are on a pathway to senescence. In the presence of an oncoprotein the TH-insulin cells are able to proliferate. The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell proliferation organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes organism description > animal > mammal > rodent > mouse |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Gail Sherman |
| Date: | 15 January 1988 |
| Date Deposited: | 29 Sep 2017 14:44 |
| Last Modified: | 29 Sep 2017 14:46 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/35222 |
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