ROS in Cancer: The Burning Question

Chio, Iok In Christine, Tuveson, David A. (May 2017) ROS in Cancer: The Burning Question. Trends in Molecular Medicine, 23 (5). pp. 411-429. ISSN 1471-4914

URL: https://www.ncbi.nlm.nih.gov/pubmed/28427863
DOI: 10.1016/j.molmed.2017.03.004

Abstract

An unanswered question in human health is whether antioxidation prevents or promotes cancer. Antioxidation has historically been viewed as chemopreventive, but emerging evidence suggests that antioxidants may be supportive of neoplasia. We posit this contention to be rooted in the fact that ROS do not operate as one single biochemical entity, but as diverse secondary messengers in cancer cells. This cautions against therapeutic strategies to increase ROS at a global level. To leverage redox alterations towards the development of effective therapies necessitates the application of biophysical and biochemical approaches to define redox dynamics and to functionally elucidate specific oxidative modifications in cancer versus normal cells. An improved understanding of the sophisticated workings of redox biology is imperative to defeating cancer.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders > pulmonary disease > oxidative stress
CSHL Authors:
Communities: CSHL labs > Tuveson lab
Depositing User: Matt Covey
Date: May 2017
Date Deposited: 20 Apr 2017 19:31
Last Modified: 19 May 2017 19:49
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34570

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