The Arabidopsis thaliana mobilome and its impact at the species level

Quadrana, L., Bortolini Silveira, A., Mayhew, G. F., LeBlanc, C., Martienssen, R. A., Jeddeloh, J. A., Colot, V. (June 2016) The Arabidopsis thaliana mobilome and its impact at the species level. Elife, 5. ISSN 2050-084X (Electronic)2050-084X (Linking)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/27258693
DOI: 10.7554/eLife.15716

Abstract

Transposable elements (TEs) are powerful motors of genome evolution yet a comprehensive assessment of recent transposition activity at the species level is lacking for most organisms. Here, using genome sequencing data for 211 Arabidopsis thaliana accessions taken from across the globe, we identify thousands of recent transposition events involving half of the 326 TE families annotated in this plant species. We further show that the composition and activity of the 'mobilome' vary extensively between accessions in relation to climate and genetic factors. Moreover, TEs insert equally throughout the genome and are rapidly purged by natural selection from gene-rich regions because they frequently affect genes, in multiple ways. Remarkably, loci controlling adaptive responses to the environment are the most frequent transposition targets observed. These findings demonstrate the pervasive, species-wide impact that a rich mobilome can have and the importance of transposition as a recurrent generator of large-effect alleles.

Item Type: Paper
Uncontrolled Keywords: A. thaliana DNA methylation spreading Gwas Transposable elements adaptation climate evolutionary biology genomics large effect alleles
Subjects: organism description > plant > Arabidopsis
bioinformatics > genomics and proteomics
Investigative techniques and equipment > assays > genome wide association studies
organism description > plant
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA expression > transposable elements
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date: 3 June 2016
Date Deposited: 01 Jul 2016 16:05
Last Modified: 01 Jul 2016 16:05
PMCID: PMC4917339
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32940

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