Integration of bacteriophage mu DNA

Bukhari, A. I., Dubow, M. S., Khatoon, H., Ambrosio, L., Debruijn, F., Ljungquist, E. (1979) Integration of bacteriophage mu DNA. Cold Spring Harb Symp Quant Biol, 43. pp. 1151-8.

URL: http://www.ncbi.nlm.nih.gov/pubmed/158469
DOI: 10.1101/SQB.1979.043.01.130

Abstract

Integrative recombination is not merely a distant evolutionary advantage for the temperate bacteriophage Mu. It is an indispensable part of the Mu life cycle. Mu growth involves apparently random insertion of its DNA into the DNA of its host bacterium Escherichia coli. As Mu DNA replicates, more and more copies of the Mu genome are dispersed throughout the host chromosome. Evidently Mu DNA continuously reacts with the host DNA. No gross disruption and degradation of host DNA has been observed during Mu growth, but various rearrangements in host DNA can occur. These rearrangements include formation of heterogeneous covalently closed circles containing Mu DNA and host DNA (Waggoner et al. 1974; Schröder et al. 1974), and Mu-mediated transposition of host sequences from one site to another (for review, see Toussaint et al. 1977).

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage

organism description > virus
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 1979
Date Deposited: 10 Aug 2016 15:50
Last Modified: 10 Aug 2016 15:50
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32665

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