Bukhari, A. I., Dubow, M. S., Khatoon, H., Ambrosio, L., Debruijn, F., Ljungquist, E. (1979) Integration of bacteriophage mu DNA. Cold Spring Harb Symp Quant Biol, 43. pp. 1151-8.
Abstract
Integrative recombination is not merely a distant evolutionary advantage for the temperate bacteriophage Mu. It is an indispensable part of the Mu life cycle. Mu growth involves apparently random insertion of its DNA into the DNA of its host bacterium Escherichia coli. As Mu DNA replicates, more and more copies of the Mu genome are dispersed throughout the host chromosome. Evidently Mu DNA continuously reacts with the host DNA. No gross disruption and degradation of host DNA has been observed during Mu growth, but various rearrangements in host DNA can occur. These rearrangements include formation of heterogeneous covalently closed circles containing Mu DNA and host DNA (Waggoner et al. 1974; Schröder et al. 1974), and Mu-mediated transposition of host sequences from one site to another (for review, see Toussaint et al. 1977).
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage organism description > virus |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | 1979 |
| Date Deposited: | 10 Aug 2016 15:50 |
| Last Modified: | 10 Aug 2016 15:50 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32665 |
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