Between the primate and 'reptilian' brain: Rodent models demonstrate the role of corticostriatal circuits in decision making

Lee, A. M., Tai, L. H., Zador, A., Wilbrecht, L. (June 2015) Between the primate and 'reptilian' brain: Rodent models demonstrate the role of corticostriatal circuits in decision making. Neuroscience, 296. pp. 66-74. ISSN 0306-4522

URL: http://www.ncbi.nlm.nih.gov/pubmed/25575943
DOI: 10.1016/j.neuroscience.2014.12.042

Abstract

Decision making can be defined as the flexible integration and transformation of information from the external world into action. Recently, the development of novel genetic tools and new behavioral paradigms has made it attractive to study behavior of all kinds in rodents. By some perspectives, rodents are not an acceptable model for the study of decision making due to their simpler behavior often attributed to their less extensive cortical development when compared to non-human primates. We argue that decision making can be approached with a common framework across species. We review insights from comparative anatomy that suggest the expansion of cortical-striatal connectivity is a key development in evolutionary increases in behavioral flexibility. We briefly review studies that establish a role for corticostriatal circuits in integrative decision making. Finally, we provide an overview of a few recent, highly complementary rodent decision making studies using genetic tools, revealing with new cellular and temporal resolution how, when and where information can be integrated and compared in striatal circuits to influence choice.

Item Type: Paper
Subjects: organism description > animal behavior
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > corticostriatal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > corticostriatal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > corticostriatal neurons

organism description > animal behavior > decision making
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits

organism description > animal > mammal > rodent
CSHL Authors:
Communities: CSHL labs > Zador lab
Depositing User: Matt Covey
Date: 18 June 2015
Date Deposited: 04 Sep 2015 18:52
Last Modified: 02 Feb 2016 15:09
PMCID: PMC4684574
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31736

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