The Sos (Son of Sevenless) Protein

Bar-Sagi, D. (May 1994) The Sos (Son of Sevenless) Protein. Trends in Endocrinology and Metabolism, 5 (4). pp. 165-169. ISSN 1043-2760

URL: http://www.ncbi.nlm.nih.gov/pubmed/18407204
DOI: 10.1016/1043-2760(94)90014-0

Abstract

The Drosophila Son of sevenless (Sos) gene functions in the signaling pathway initiated by the Sevenless receptor tyrosine kinase. It encodes the Drosophila homologue of CDC25, an activator of Ras in the yeast Saccharomyces cerevisiae. Two widely expressed mammalian homologues of Sos (mSos) have now been identified and characterized They encode for 150-kD proteins that ave Ras-specific guanine nucleotide exchange factors. Generic and biochemical studies indicate that Sos proteins bind directly to the SH2- and SH3-domain-containing adaptor protein GRB2/Drk. This interaction defines a pathway by which receptor tyrosine kinases can communicate with Ras.

Item Type: Paper
Uncontrolled Keywords: GUANINE-NUCLEOTIDE EXCHANGE RECEPTOR TYROSINE KINASES EPIDERMAL GROWTH-FACTOR SACCHAROMYCES-CEREVISIAE SH3 DOMAINS RAS ACTIVATOR GENE-PRODUCT EGF RECEPTOR CDC25 GENE GRB2
Subjects: organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Ras
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: May 1994
Date Deposited: 01 May 2015 16:11
Last Modified: 01 May 2015 16:11
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31489

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