Bar-Sagi, D. (May 1994) The Sos (Son of Sevenless) Protein. Trends in Endocrinology and Metabolism, 5 (4). pp. 165-169. ISSN 1043-2760
Abstract
The Drosophila Son of sevenless (Sos) gene functions in the signaling pathway initiated by the Sevenless receptor tyrosine kinase. It encodes the Drosophila homologue of CDC25, an activator of Ras in the yeast Saccharomyces cerevisiae. Two widely expressed mammalian homologues of Sos (mSos) have now been identified and characterized They encode for 150-kD proteins that ave Ras-specific guanine nucleotide exchange factors. Generic and biochemical studies indicate that Sos proteins bind directly to the SH2- and SH3-domain-containing adaptor protein GRB2/Drk. This interaction defines a pathway by which receptor tyrosine kinases can communicate with Ras.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | GUANINE-NUCLEOTIDE EXCHANGE RECEPTOR TYROSINE KINASES EPIDERMAL GROWTH-FACTOR SACCHAROMYCES-CEREVISIAE SH3 DOMAINS RAS ACTIVATOR GENE-PRODUCT EGF RECEPTOR CDC25 GENE GRB2 |
| Subjects: | organism description > animal > insect > Drosophila bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Ras bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | May 1994 |
| Date Deposited: | 01 May 2015 16:11 |
| Last Modified: | 01 May 2015 16:11 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31489 |
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