From guide to target: molecular insights into eukaryotic RNA-interference machinery

Ipsaro, J. J., Joshua-Tor, L. (2015) From guide to target: molecular insights into eukaryotic RNA-interference machinery. Nat Struct Mol Biol, 22 (1). pp. 20-28. ISSN 1545-9985

URL: http://www.ncbi.nlm.nih.gov/pubmed/25565029
DOI: 10.1038/nsmb.2931

Abstract

Since its relatively recent discovery, RNA interference (RNAi) has emerged as a potent, specific and ubiquitous means of gene regulation. Through a number of pathways that are conserved in eukaryotes from yeast to humans, small noncoding RNAs direct molecular machinery to silence gene expression. In this Review, we focus on mechanisms and structures that govern RNA silencing in higher organisms. In addition to highlighting recent advances, we discuss parallels and differences among RNAi pathways. Together, the studies reviewed herein reveal the versatility and programmability of RNA-induced silencing complexes and emphasize the importance of both upstream biogenesis and downstream silencing factors.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
CSHL Authors:
Communities: CSHL labs > Joshua-Tor lab
Depositing User: Matt Covey
Date Deposited: 16 Jan 2015 20:24
Last Modified: 13 Jan 2017 20:21
PMCID: PMC4450863
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31137

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