Ipsaro, J. J., Joshua-Tor, L. (January 2015) From guide to target: molecular insights into eukaryotic RNA-interference machinery. Nat Struct Mol Biol, 22 (1). pp. 20-28. ISSN 1545-9985 (Public Dataset)
Abstract
Since its relatively recent discovery, RNA interference (RNAi) has emerged as a potent, specific and ubiquitous means of gene regulation. Through a number of pathways that are conserved in eukaryotes from yeast to humans, small noncoding RNAs direct molecular machinery to silence gene expression. In this Review, we focus on mechanisms and structures that govern RNA silencing in higher organisms. In addition to highlighting recent advances, we discuss parallels and differences among RNAi pathways. Together, the studies reviewed herein reveal the versatility and programmability of RNA-induced silencing complexes and emphasize the importance of both upstream biogenesis and downstream silencing factors.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote |
| CSHL Authors: | |
| Communities: | CSHL labs > Joshua-Tor lab |
| Depositing User: | Matt Covey |
| Date: | 7 January 2015 |
| Date Deposited: | 16 Jan 2015 20:24 |
| Last Modified: | 01 Sep 2017 16:01 |
| PMCID: | PMC4450863 |
| Related URLs: | |
| Dataset ID: | |
| URI: | https://repository.cshl.edu/id/eprint/31137 |
Actions (login required)
 |
Administrator's edit/view item |