Long-term memory stabilized by noise-induced rehearsal

Wei, Y., Koulakov, A. A. (November 2014) Long-term memory stabilized by noise-induced rehearsal. Journal of Neuroscience, 34 (47). pp. 15804-15. ISSN 0270-6474

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URL: http://www.ncbi.nlm.nih.gov/pubmed/25411507
DOI: 10.1523/jneurosci.3929-12.2014

Abstract

Cortical networks can maintain memories for decades despite the short lifetime of synaptic strengths. Can a neural network store long-lasting memories in unstable synapses? Here, we study the effects of ongoing spike-timing-dependent plasticity (STDP) on the stability of memory patterns stored in synapses of an attractor neural network. We show that certain classes of STDP rules can stabilize all stored memory patterns despite a short lifetime of synapses. In our model, unstructured neural noise, after passing through the recurrent network connections, carries the imprint of all memory patterns in temporal correlations. STDP, combined with these correlations, leads to reinforcement of all stored patterns, even those that are never explicitly visited. Our findings may provide the functional reason for irregular spiking displayed by cortical neurons and justify models of system memory consolidation. Therefore, we propose that irregular neural activity is the feature that helps cortical networks maintain stable connections.

Item Type: Paper
Subjects: organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Koulakov lab
Depositing User: Matt Covey
Date: 19 November 2014
Date Deposited: 26 Nov 2014 20:48
Last Modified: 25 Oct 2018 16:14
PMCID: PMC4236406
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30933

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