Fibroblast heterogeneity in the cancer wound

Ohlund, D., Elyada, E., Tuveson, D. (July 2014) Fibroblast heterogeneity in the cancer wound. Journal of Experimental Medicine, 211 (8). pp. 1503-23. ISSN 0022-1007

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URL: http://www.ncbi.nlm.nih.gov/pubmed/25071162
DOI: 10.1084/jem.20140692

Abstract

Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy.

Item Type: Paper
Subjects: diseases & disorders > cancer > drugs and therapies
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts
CSHL Authors:
Communities: CSHL labs > Tuveson lab
Depositing User: Matt Covey
Date: 28 July 2014
Date Deposited: 08 Aug 2014 15:46
Last Modified: 08 Aug 2014 15:46
PMCID: PMC4113948
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30676

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