Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer

Das, S., Krainer, A. R. (May 2014) Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer. Molecular Cancer Research, 12 (9). pp. 1195-1204. ISSN 1541-7786

URL: http://www.ncbi.nlm.nih.gov/pubmed/24807918
DOI: 10.1158/1541-7786.mcr-14-0131

Abstract

Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splicing regulators. Since its discovery, over two decades ago, SRSF1 has been repeatedly surprising and intriguing investigators by the plethora of complex biological pathways it regulates. These include several key aspects of mRNA metabolism, such as mRNA splicing, stability, and translation, as well as other mRNA-independent processes, such as miRNA (miR) processing, protein sumoylation, and the nucleolar-stress response. In this review, the structural features of SRSF1 are discussed as they relate to the intricate mechanism of splicing and the multiplicity of functions it performs. Similarly, a list of relevant alternatively spliced transcripts and SRSF1 interacting proteins is provided. Finally, emphasis is given to the deleterious consequences of overexpression of the SRSF1 proto-oncogene in human cancers, and the complex mechanisms and pathways underlying SRSF1-mediated transformation. The accumulated knowledge about SRSF1 provides critical insight into the integral role it plays in maintaining cellular homeostasis, and suggests new targets for anti-cancer therapy.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA regulation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > splicing factor
CSHL Authors:
Communities: CSHL labs > Krainer lab
Depositing User: Matt Covey
Date: 7 May 2014
Date Deposited: 15 May 2014 19:14
Last Modified: 09 Oct 2014 16:44
PMCID: PMC4163531
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30139

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