Auditory Thalamus and Auditory Cortex Are Equally Modulated by Context during Flexible Categorization of Sounds

Jaramillo, S., Borges, K., Zador, A. M. (April 2014) Auditory Thalamus and Auditory Cortex Are Equally Modulated by Context during Flexible Categorization of Sounds. Journal of Neuroscience, 34 (15). pp. 5291-301. ISSN 0270-6474

[img]
Preview
PDF (Paper)
Zador J Neuroscience 2014.pdf - Published Version

Download (3089Kb) | Preview
URL: http://www.ncbi.nlm.nih.gov/pubmed/24719107
DOI: 10.1523/jneurosci.4888-13.2014

Abstract

In a dynamic world, animals must adapt rapidly to changes in the meaning of environmental cues. Such changes can influence the neural representation of sensory stimuli. Previous studies have shown that associating a stimulus with a reward or punishment can modulate neural activity in the auditory cortex (AC) and its thalamic input, the medial geniculate body (MGB). However, it is not known whether changes in stimulus-action associations alone can also modulate neural responses in these areas. We designed a categorization task for rats in which the boundary that separated low- from high-frequency sounds varied several times within a behavioral session, thus allowing us to manipulate the action associated with some sounds without changing the associated reward. We developed a computational model that accounted for the rats' performance and compared predictions from this model with sound-evoked responses from single neurons in AC and MGB in animals performing this task. We found that the responses of 15% of AC neurons and 16% of MGB neurons were modulated by changes in stimulus-action association and that the magnitude of the modulation was comparable between the two brain areas. Our results suggest that the AC and thalamus play only a limited role in mediating changes in associations between acoustic stimuli and behavioral responses.

Item Type: Paper
Subjects: organism description > animal behavior
organism description > animal behavior > auditory
organs, tissues, organelles, cell types and functions > tissues types and functions > auditory cortex
organs, tissues, organelles, cell types and functions > tissues types and functions > thalamus
CSHL Authors:
Communities: CSHL labs > Zador lab
Depositing User: Matt Covey
Date: 9 April 2014
Date Deposited: 18 Apr 2014 16:33
Last Modified: 24 Apr 2015 16:25
PMCID: PMC3983805
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29771

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving