Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features

Uchida, N., Takahashi, Y. K., Tanifuji, M., Mori, K. (2000) Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features. Nature Neuroscience, 3 (10). pp. 1035-1043. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/11017177
DOI: 10.1038/79857

Abstract

Psychophysical studies indicate that structural features of odorants differentially influence their perceived odor. In the olfactory bulb (OB), odorants are represented by ensembles of activated glomeruli. Here we used optical imaging of intrinsic signals to examine how these structural features are represented spatially in the sensory map of the rat OB. We found that the dorsal OB contained two topographically fixed domains; constituent glomeruli in each domain could be activated by odorants with particular functional groups. Within each domain, other structural features such as carbon chain length and branching were represented by local differences in patterns. These results suggest that structural features are categorized into two classes, primary features (functional groups) that characterize each domain, and secondary features that are represented by local positions within each domain. Such hierarchical representations of different structural features correlate well with psychophysical structure-odor relationships.

Item Type: Paper
Uncontrolled Keywords: MITRAL TUFTED CELLS FUNCTIONAL EXPRESSION 2-DEOXYGLUCOSE UPTAKE HOMOLOGOUS SERIES RECEPTOR RABBIT RAT COMBINATORIAL MOLECULES NEURONS
Subjects: organism description > animal behavior
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits

organism description > animal behavior > olfactory
organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb
CSHL Authors:
Communities: CSHL labs > Mainen lab
Depositing User: Matt Covey
Date Deposited: 29 Jan 2014 15:57
Last Modified: 29 Jan 2014 15:57
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29422

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving