Implications of intratumour heterogeneity for treatment stratification

Crockford, A., Jamal-Hanjani, M., Hicks, J., Swanton, C. (January 2014) Implications of intratumour heterogeneity for treatment stratification. Journal of Pathology, 232 (2). pp. 264-273. ISSN 00223417 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/24115146
DOI: 10.1002/path.4270

Abstract

Despite advances in the diagnosis and treatment of cancer, the majority of advanced metastatic solid tumours remain incurable. Differential gene expression, somatic mutational status, tumour-specific genetic signatures and micro-environmental selection pressures within individual tumours have implications for the success of predictive assays to guide therapeutic intervention. In this review we discuss the evidence for genetic and phenotypic heterogeneity and its potential implications for clinical decision making. We highlight areas of research that could be improved in order to better stratify patient treatment. We also discuss the predictive potential of patient-derived models of tumour response, including xenograft and cell line-based systems within the context of intratumour heterogeneity. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Item Type: Paper
Uncontrolled Keywords: intratumour heterogeneity patient-derived xenograft models personalized medicine
Subjects: diseases & disorders > cancer
diseases & disorders
therapies
bioinformatics > genomics and proteomics > personal genomes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes > personal genomes

therapies > personalised therapy
CSHL Authors:
Communities: CSHL labs > Hicks lab
Depositing User: Matt Covey
Date: January 2014
Date Deposited: 07 Jan 2014 17:55
Last Modified: 07 Jan 2014 17:55
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29203

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