Crockford, A., Jamal-Hanjani, M., Hicks, J., Swanton, C. (January 2014) Implications of intratumour heterogeneity for treatment stratification. Journal of Pathology, 232 (2). pp. 264-273. ISSN 00223417 (ISSN)
Abstract
Despite advances in the diagnosis and treatment of cancer, the majority of advanced metastatic solid tumours remain incurable. Differential gene expression, somatic mutational status, tumour-specific genetic signatures and micro-environmental selection pressures within individual tumours have implications for the success of predictive assays to guide therapeutic intervention. In this review we discuss the evidence for genetic and phenotypic heterogeneity and its potential implications for clinical decision making. We highlight areas of research that could be improved in order to better stratify patient treatment. We also discuss the predictive potential of patient-derived models of tumour response, including xenograft and cell line-based systems within the context of intratumour heterogeneity. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | intratumour heterogeneity patient-derived xenograft models personalized medicine |
| Subjects: | diseases & disorders > cancer diseases & disorders therapies bioinformatics > genomics and proteomics > personal genomes bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes > personal genomes therapies > personalised therapy |
| CSHL Authors: | |
| Communities: | CSHL labs > Hicks lab |
| Depositing User: | Matt Covey |
| Date: | January 2014 |
| Date Deposited: | 07 Jan 2014 17:55 |
| Last Modified: | 07 Jan 2014 17:55 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29203 |
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