The House & Garden guide to chromatin remodelling

Martienssen, R., Henikoff, S. (1999) The House & Garden guide to chromatin remodelling. Nature Genetics, 22 (1). pp. 6-7. ISSN 1061-4036

URL: http://www.ncbi.nlm.nih.gov/pubmed/10319848
DOI: 10.1038/8708

Abstract

In our gene-centred society, a chromosome is often regarded merely as an accomodation for genes, providing replication, segregation and other housekeeping functions for its many residents. The transcription of genes garners nearly all of our attention, and we tend to consider the customized gene-by-gene regulation of transcription to be the key to development and physiology. During the past few years, however, the importance of chromosomes and chromatin in the regulation of gene expression has come to the fore, with the recognition that chromatin remodelling and histone acetylation influence transcription1. This has been revealed in large part by genetic interactions between genes encoding subunits of remodelling complexes and their targets2, 3. And yet genes account for only a minor percentage of the eukaryotic genome; non-genic regions are similarly packaged into nucleosomes. Focus on gene-based processes may obscure the generality of nucleosome displacement for maintaining and packaging chromosomes.

Item Type: Paper
Uncontrolled Keywords: dna methyltransferase arabidopsis methylation transcription yeast genes probe
Subjects: organism description > plant > Arabidopsis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA methylation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > methyltransferase
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date Deposited: 13 Dec 2013 16:25
Last Modified: 13 Dec 2013 16:25
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28991

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