Lateralized organization of the cerebellum in a silent verbal fluency task: a functional magnetic resonance imaging study in healthy volunteers

Hubrich-Ungureanu, P., Kaemmerer, N., Henn, F. A., Braus, D. F. (February 2002) Lateralized organization of the cerebellum in a silent verbal fluency task: a functional magnetic resonance imaging study in healthy volunteers. Neuroscience Letters, 319 (2). pp. 91-4. ISSN 03043940 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11825678
DOI: 10.1016/S0304-3940(01)02566-6

Abstract

Functionally, the cerebellum is not only involved in motor control but is also thought to influence higher cognitive function including language. Anatomical data would suggest crossed reciprocal connections between the cerebellum and higher order cortical association areas. In the following study, one left- and one right-handed female volunteer underwent functional magnetic resonance imaging in a conventional block design. Regions of activation were detected after performance of a silent verbal fluency task inside the scanner. In the right-handed volunteer we found an activation of the left fronto-parietal cortex and the right cerebellar hemisphere, while in the left-handed volunteer the activation was seen in the right fronto-parieto-temporal cortex and the left cerebellar hemisphere. These initial results demonstrate that cerebellar activation is contralateral to the activation of the frontal cortex even under conditions of different language dominance. They provide evidence for the hypothesis of a lateralized organization of the cerebellum crossed to the cerebral hemispheres in supporting higher cognitive function.

Item Type: Paper
Uncontrolled Keywords: Adult Brain Mapping Cerebellum/anatomy & histology/ physiology Cerebral Cortex/anatomy & histology/ physiology Cognition/ physiology Female Functional Laterality/ physiology Humans Magnetic Resonance Imaging Neural Pathways/anatomy & histology/ physiology Neuropsychological Tests Verbal Behavior/ physiology
Subjects: organism description > animal behavior
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebellum
Investigative techniques and equipment > magnetic resonance imaging
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 15 February 2002
Date Deposited: 08 Jan 2014 16:41
Last Modified: 08 Jan 2014 16:41
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28723

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