Activation of transposable elements during aging and neuronal decline in Drosophila

Li, W., Prazak, L., Chatterjee, N., Gruninger, S., Krug, L., Theodorou, D., Dubnau, J. (2013) Activation of transposable elements during aging and neuronal decline in Drosophila. Nature Neuroscience, 16. pp. 529-531. ISSN 1546-1726 (Electronic)1097-6256 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/23563579
DOI: 10.1038/nn.3368

Abstract

We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA expression > transposable elements
CSHL Authors:
Communities: CSHL Post Doctoral Fellows
CSHL labs > Dubnau lab
Watson School > Publications
Highlight: Dubnau, Josh T.
Depositing User: Matt Covey
Date Deposited: 10 Apr 2013 18:44
Last Modified: 03 Apr 2015 16:50
PMCID: PMC3821974
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28105

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