Li, W., Prazak, L., Chatterjee, N., Gruninger, S., Krug, L., Theodorou, D., Dubnau, J. (April 2013) Activation of transposable elements during aging and neuronal decline in Drosophila. Nature Neuroscience, 16. pp. 529-531. ISSN 1546-1726 (Electronic)1097-6256 (Linking)
DOI: 10.1038/nn.3368
Abstract
We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification organism description > animal > insect > Drosophila bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA expression > transposable elements |
| CSHL Authors: | |
| Communities: | CSHL Post Doctoral Fellows CSHL labs > Dubnau lab School of Biological Sciences > Publications |
| Highlight: | Dubnau, Josh T. |
| Depositing User: | Matt Covey |
| Date: | 7 April 2013 |
| Date Deposited: | 10 Apr 2013 18:44 |
| Last Modified: | 03 Apr 2015 16:50 |
| PMCID: | PMC3821974 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28105 |
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