Reduced cell proliferation in the dentate gyrus is not correlated with the development of learned helplessness

Vollmayr, B., Simonis, C., Weber, S., Gass, P., Henn, F. (November 2003) Reduced cell proliferation in the dentate gyrus is not correlated with the development of learned helplessness. Biol Psychiatry, 54 (10). pp. 1035-40. ISSN 0006-3223 (Print)0006-3223 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/14625145
DOI: 10.1016/S0006-3223(03)00527-4

Abstract

BACKGROUND: A plethora of indirect findings suggests that mood disorders may be caused by or result in structural changes in the brain, namely decreased hippocampal cell proliferation. METHODS: To test for these hypotheses, we used a rat model of depression, learned helplessness. Moderate unpredictable and inescapable foot shocks induced learned helplessness only in a portion of the rats. Rats that showed helpless behavior were compared to those behaving normally after inescapable shock. Proliferating cells in the dentate gyrus were labeled with BrdU (bromodeoxyuridine). RESULTS: Helpless behavior appeared before the decrease of dentate gyrus cell proliferation was maximal. Cell proliferation was decreased to the same extent in animals that developed helplessness as those that were not helpless. Furthermore, immobilization stress, which reduced the rate of cell proliferation, did not induce learned helplessness. CONCLUSION: These results are in line with reports that the rate of dentate gyrus cell proliferation is acutely down-regulated by stress, but the development of helpless behavior does not correlate with this process. Further studies will have to clarify if during learned helpless behavior neurogenesis is impaired by altered differentiation or survival of cells.

Item Type: Paper
Uncontrolled Keywords: Analysis of Variance Animals Behavior, Animal Bromodeoxyuridine/pharmacokinetics Cell Count Cell Division Dentate Gyrus/metabolism/ pathology/radiation effects Electroshock/methods Helplessness, Learned Immobilization Immunohistochemistry Male Radiation-Sensitizing Agents/pharmacokinetics Rats Rats, Sprague-Dawley Time Factors
Subjects: diseases & disorders
diseases & disorders > mental disorders
diseases & disorders > mental disorders > mood disorders
organism description > animal behavior
diseases & disorders > mental disorders > mood disorders > depression
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 15 November 2003
Date Deposited: 01 Apr 2013 18:40
Last Modified: 01 Apr 2013 18:40
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28009

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