The replicon model and eukaryotic chromosomes

Bell, S. P., Marahrens, Y., Rao, H., Stillman, B. (1993) The replicon model and eukaryotic chromosomes. Cold Spring Harbor Symposia on Quantitative Biology, 58. pp. 435-442. ISSN 00917451 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7956057
DOI: 10.1101/SQB.1993.058.01.050

Abstract

Thirty years ago, Jacob, Cuzin, and Brenner proposed the replicon model of DNA replication to describe the regulation of Escherichia coli chromosomal duplication (Jacob et al. 1964). This model predicted that a positive trans-acting protein, called the initiator, would activate DNA replication through a cis-acting sequence called the replicator. Subsequent studies demonstrated the validity of this model and identified the dnaA protein as the initiator and oriC as the replicator for replication of the E. coli chromosome (Kornberg and Baker 1991). The finding that a number of bacteriophage and eukaryotic viruses use a similar mechanism to replicate their genomes supports the generality of this model (Challberg and Kelly 1989; Stillman 1989). In eukaryotic cells, the problem of chromosomal replication is much more complex. Instead of a single origin of replication, hundreds of origins must be coordinately regulated. In addition, the timing and extent of replication are precisely controlled during the...

Item Type: Paper
Uncontrolled Keywords: chromosome duplication conference paper dna replication origin dna sequence nonhuman priority journal replicon saccharomyces cerevisiae transcription initiation Chromosomes DNA Replication DNA, Fungal DNA-Binding Proteins Eukaryotic Cells Fungal Proteins Genes, Fungal Models, Genetic Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types

organs, tissues, organelles, cell types and functions > cell types and functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote

organs, tissues, organelles, cell types and functions
CSHL Authors:
Communities: CSHL labs > Stillman lab
Highlight: Stillman, Bruce W.
Depositing User: Matt Covey
Date Deposited: 08 Mar 2013 18:36
Last Modified: 20 Jun 2017 20:00
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27737

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