Bell, S. P., Marahrens, Y., Rao, H., Stillman, B.
(1993)
The replicon model and eukaryotic chromosomes.
Cold Spring Harbor Symposia on Quantitative Biology, 58.
pp. 435-442.
ISSN 00917451 (ISSN)
Abstract
Thirty years ago, Jacob, Cuzin, and Brenner proposed the replicon model of DNA replication to describe the regulation of Escherichia coli chromosomal duplication (Jacob et al. 1964). This model predicted that a positive trans-acting protein, called the initiator, would activate DNA replication through a cis-acting sequence called the replicator. Subsequent studies demonstrated the validity of this model and identified the dnaA protein as the initiator and oriC as the replicator for replication of the E. coli chromosome (Kornberg and Baker 1991). The finding that a number of bacteriophage and eukaryotic viruses use a similar mechanism to replicate their genomes supports the generality of this model (Challberg and Kelly 1989; Stillman 1989). In eukaryotic cells, the problem of chromosomal replication is much more complex. Instead of a single origin of replication, hundreds of origins must be coordinately regulated. In addition, the timing and extent of replication are precisely controlled during the...
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
chromosome duplication
conference paper
dna replication origin
dna sequence
nonhuman
priority journal
replicon
saccharomyces cerevisiae
transcription initiation
Chromosomes
DNA Replication
DNA, Fungal
DNA-Binding Proteins
Eukaryotic Cells
Fungal Proteins
Genes, Fungal
Models, Genetic
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S. |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Stillman lab |
| Highlight: |
Stillman, Bruce W. |
| Depositing User: |
Matt Covey
|
| Date: |
1993 |
| Date Deposited: |
08 Mar 2013 18:36 |
| Last Modified: |
20 Jun 2017 20:00 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/27737 |
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