Gene-environment interaction in hyperkinetic conduct disorder (HD + CD) as indicated by season of birth variations in dopamine receptor (DRD4) gene polymorphism

Seeger, G., Schloss, P., Schmidt, M. H., Ruter-Jungfleisch, A., Henn, F. A. (August 2004) Gene-environment interaction in hyperkinetic conduct disorder (HD + CD) as indicated by season of birth variations in dopamine receptor (DRD4) gene polymorphism. Neurosci Lett, 366 (3). pp. 282-6. ISSN 0304-3940 (Print)0304-3940 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/15288435
DOI: 10.1016/j.neulet.2004.05.049

Abstract

Recently, an interaction between season of birth and the expression of candidate genes has been suggested. Season of birth variations in tryptophan hydroxylase (TPH), the serotonin transporter (5-HTTLPR) and the dopamine D4 receptor (DRD4) gene polymorphisms are different for affective disorders and schizophrenia. The DRD4 gene has been postulated as a candidate gene for attention-deficit-hyperactivity disorder (ADHD), equivalent to hyperkinetic disorder (HD). The seven-repeat long variant of this gene (DRD4*7) in comparison to the short repeat variants of the DRD4 gene polymorphism, has been found to be associated with ADHD. A seasonal pattern of birth has also been proposed for different subtypes of ADHD. Therefore, in a subgroup of children with HD and conduct disorder (CD) and in healthy controls, we investigated a possible association between the DRD4*7 allele and HD + CD in association with the season of birth. Supporting this hypothesis, we found an interaction between the seasons of birth and the expression of the DRD4 candidate gene in children with HD + CD as well as in controls, which differ significantly from each other. Depending on the season of birth, children carrying the DRD4*7R allele showed different relative risks for developing HD + CD.

Item Type: Paper
Uncontrolled Keywords: Adolescent Attention Deficit Disorder with Hyperactivity/complications/ genetics Birth Rate Chi-Square Distribution Child Conduct Disorder/complications/ genetics Environment Genetic Predisposition to Disease Humans Incidence Polymorphism, Genetic Receptors, Dopamine D2/ genetics Receptors, Dopamine D4 Seasons Tandem Repeat Sequences/genetics
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein receptor
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 19 August 2004
Date Deposited: 04 Mar 2013 20:37
Last Modified: 04 Mar 2013 20:37
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27709

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