Evidence for Network Evolution in an Arabidopsis Interactome Map

Consortium, Arabidopsis Interactome Mapping (2011) Evidence for Network Evolution in an Arabidopsis Interactome Map. Science, 333 (6042). pp. 601-607.

URL: http://www.ncbi.nlm.nih.gov/pubmed/21798944
DOI: 10.1126/science.1203877

Abstract

Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.

Item Type: Paper
Subjects: organism description > plant > Arabidopsis
bioinformatics
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > design > protein network design
organism description > plant
CSHL Authors:
Communities: CSHL labs > Ware lab
Depositing User: Matt Covey
Date Deposited: 05 Feb 2013 16:18
Last Modified: 05 Feb 2013 16:18
PMCID: PMC3170756
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27204

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