Consortium, Arabidopsis Interactome Mapping (July 2011) Evidence for Network Evolution in an Arabidopsis Interactome Map. Science, 333 (6042). pp. 601-607.
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Abstract
Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > plant > Arabidopsis bioinformatics bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > design > protein network design organism description > plant |
| CSHL Authors: | |
| Communities: | CSHL labs > Ware lab |
| Depositing User: | Matt Covey |
| Date: | 29 July 2011 |
| Date Deposited: | 05 Feb 2013 16:18 |
| Last Modified: | 02 Oct 2019 15:25 |
| PMCID: | PMC3170756 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27204 |
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