RNAi: An ever-growing puzzle

Denli, A. M., Hannon, G. J. (2003) RNAi: An ever-growing puzzle. Trends in Biochemical Sciences, 28 (4). pp. 196-201. ISSN 09680004 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/12713903
DOI: 10.1016/s0968-0004(03)00058-6

Abstract

In recent years, sequence-specific gene silencing has been an area of increasing focus, both because of its interesting biology and because of its power as an experimental tool. A growing understanding of one such phenomenon, RNA interference (RNAi), has provided clues that many homology-dependent gene-silencing mechanisms share a common trigger, double-stranded RNA. Recent findings that RNAi and related pathways are involved not only in the response to exogenous pathogenic and endogenous parasitic nucleic acids but also in basic cellular processes, such as gene regulation and heterochromatin formation, have further fueled interest in this rapidly expanding field.

Item Type: Paper
Uncontrolled Keywords: double stranded RNA nucleic acid RNA biology gene control gene silencing heterochromatin nonhuman parasite pathogenicity priority journal review sequence homology Animals Endoribonucleases Humans Ribonuclease III RNA Interference RNA, Double-Stranded RNA, Messenger RNA-Induced Silencing Complex
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
CSHL Authors:
Communities: CSHL labs > Hannon lab
Watson School > Publications
Depositing User: Matt Covey
Date: 2003
Date Deposited: 09 Jan 2013 16:51
Last Modified: 19 Sep 2014 14:36
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26458

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