Denli, A. M., Hannon, G. J. (2003) RNAi: An ever-growing puzzle. Trends in Biochemical Sciences, 28 (4). pp. 196-201. ISSN 09680004 (ISSN)
Abstract
In recent years, sequence-specific gene silencing has been an area of increasing focus, both because of its interesting biology and because of its power as an experimental tool. A growing understanding of one such phenomenon, RNA interference (RNAi), has provided clues that many homology-dependent gene-silencing mechanisms share a common trigger, double-stranded RNA. Recent findings that RNAi and related pathways are involved not only in the response to exogenous pathogenic and endogenous parasitic nucleic acids but also in basic cellular processes, such as gene regulation and heterochromatin formation, have further fueled interest in this rapidly expanding field.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | double stranded RNA nucleic acid RNA biology gene control gene silencing heterochromatin nonhuman parasite pathogenicity priority journal review sequence homology Animals Endoribonucleases Humans Ribonuclease III RNA Interference RNA, Double-Stranded RNA, Messenger RNA-Induced Silencing Complex |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi |
| CSHL Authors: | |
| Communities: | CSHL labs > Hannon lab School of Biological Sciences > Publications |
| Depositing User: | Matt Covey |
| Date: | 2003 |
| Date Deposited: | 09 Jan 2013 16:51 |
| Last Modified: | 19 Sep 2014 14:36 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26458 |
Actions (login required)
 |
Administrator's edit/view item |