Stress Resistance Conferred by Neuronal Expression of Dominant-Negative Rac in Adult Drosophila melanogaster

Shuai, Y. C., Zhang, Y. S., Gao, L. W., Zhong, Y. (March 2011) Stress Resistance Conferred by Neuronal Expression of Dominant-Negative Rac in Adult Drosophila melanogaster. Journal of Neurogenetics, 25 (1-2). pp. 35-39. ISSN 0167-7063

URL: http://www.ncbi.nlm.nih.gov/pubmed/21563892
DOI: 10.3109/01677063.2011.573891

Abstract

How does brain coordinate physiological and behavioral responses to achieve survival in adverse environment is intriguing yet complicated. During studies of the small G protein Rac's role in learning and memory, the authors unexpectedly observed that neuronal expression of dominant-negative Rac in adult Drosophila remarkably enhanced the survival of animals in various stress conditions, including oxidation, desiccation, starvation, and heat. The elevated stress resistance was not accompanied by a reduction in female fecundity or a change in whole-body lipid storage. The observation therefore implies the involvement of small G protein Rac in neuronal regulation of global stress responses.</.

Item Type: Paper
Uncontrolled Keywords: Drosophila Rac stress resistance extended life longevity guidance gtpases span
Subjects: organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > Rac
organs, tissues, organelles, cell types and functions > organs types and functions > brain
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression
CSHL Authors:
Communities: CSHL labs > Zhong lab
CSHL Post Doctoral Fellows
Depositing User: CSHL Librarian
Date: March 2011
Date Deposited: 28 Mar 2012 19:21
Last Modified: 03 May 2013 14:55
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25600

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