Development of GABA innervation in the cerebral and cerebellar cortices

Huang, Z. J., Di Cristo, G., Ango, F. (2007) Development of GABA innervation in the cerebral and cerebellar cortices. Nat Rev Neurosci, 8 (9). pp. 673-686. ISSN 1471-0048

URL: https://www.ncbi.nlm.nih.gov/pubmed/17704810
DOI: 10.1038/nrn2188

Abstract

In many areas of the vertebrate brain, such as the cerebral and cerebellar cortices, neural circuits rely on inhibition mediated by GABA (gamma-aminobutyric acid) to shape the spatiotemporal patterns of electrical signalling. The richness and subtlety of inhibition are achieved by diverse classes of interneurons that are endowed with distinct physiological properties. In addition, the axons of interneurons display highly characteristic and class-specific geometry and innervation patterns, and thereby distribute their output to discrete spatial domains, cell types and subcellular compartments in neural networks. The cellular and molecular mechanisms that specify and modify inhibitory innervation patterns are only just beginning to be understood.

Item Type: Paper
Uncontrolled Keywords: GLUTAMIC-ACID DECARBOXYLASE CELL-ADHESION MOLECULES RAT VISUAL-CORTEX INTERNEURON DIVERSITY SERIES ACTION-POTENTIAL INITIATION GAMMA-AMINOBUTYRIC-ACID SYNAPTIC RELEASE SITES BARREL FIELD CORTEX NEUROTROPHIC FACTOR MESSENGER-RNA
Subjects: bioinformatics > genomics and proteomics > small molecules > GABA
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
organism description > animal behavior > visual
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date Deposited: 14 Nov 2011 17:32
Last Modified: 10 Jan 2017 15:52
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23042

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