Slicing and spreading of heterochromatic silencing by RNA interference

Locke, S. M., Martienssen, R. A. (2006) Slicing and spreading of heterochromatic silencing by RNA interference. Cold Spring Harbor Symposia on Quantitative Biology, 71. pp. 497-503. ISSN 00917451 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/17381332
DOI: 10.1101/sqb.2006.71.062

Abstract

RNA interference (RNAi) can mediate gene silencing posttranscriptionally by target RNA cleavage, or transcriptionally by chromatin and DNA modification. Argonaute is an essential component of the RNAi machinery that displays endonucleolytic activity guided by bound small RNAs. This slicing activity has recently been shown to be required for gene silencing and spreading of histone modifications characteristic of heterochromatin in Schizosaccharomyces pombe. Argonaute proteins with catalytic and nucleic acid binding capacities are found to function in RNAi within both the plant and animal kingdoms. Here we review the requirement of slicing for silencing and spreading in S. pombe, plants, and humans.

Item Type: Paper
Uncontrolled Keywords: Animals DNA Methylation DNA Plant genetics metabolism Gene Silencing Heterochromatin genetics metabolism Humans Models Genetic Peptide Initiation Factors genetics/metabolism Plants genetics/metabolism RNA Interference RNA, Fungal genetics metabolism RNA Plant genetics/metabolism Repressor Proteins genetics/metabolism Schizosaccharomyces genetics/metabolism Schizosaccharomyces pombe Proteins genetics/metabolism
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
organism description > yeast > Saccharomyces
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > argonaute proteins
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Watson School > Publications
Depositing User: CSHL Librarian
Date: 2006
Date Deposited: 12 Dec 2011 16:51
Last Modified: 30 Sep 2014 15:27
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22853

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