Locke, S. M., Martienssen, R. A. (2006) Slicing and spreading of heterochromatic silencing by RNA interference. Cold Spring Harbor Symposia on Quantitative Biology, 71. pp. 497-503. ISSN 00917451 (ISSN)
Abstract
RNA interference (RNAi) can mediate gene silencing posttranscriptionally by target RNA cleavage, or transcriptionally by chromatin and DNA modification. Argonaute is an essential component of the RNAi machinery that displays endonucleolytic activity guided by bound small RNAs. This slicing activity has recently been shown to be required for gene silencing and spreading of histone modifications characteristic of heterochromatin in Schizosaccharomyces pombe. Argonaute proteins with catalytic and nucleic acid binding capacities are found to function in RNAi within both the plant and animal kingdoms. Here we review the requirement of slicing for silencing and spreading in S. pombe, plants, and humans.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals DNA Methylation DNA Plant genetics metabolism Gene Silencing Heterochromatin genetics metabolism Humans Models Genetic Peptide Initiation Factors genetics/metabolism Plants genetics/metabolism RNA Interference RNA, Fungal genetics metabolism RNA Plant genetics/metabolism Repressor Proteins genetics/metabolism Schizosaccharomyces genetics/metabolism Schizosaccharomyces pombe Proteins genetics/metabolism |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi organism description > yeast > Saccharomyces bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > argonaute proteins |
| CSHL Authors: | |
| Communities: | CSHL labs > Martienssen lab School of Biological Sciences > Publications |
| Depositing User: | CSHL Librarian |
| Date: | 2006 |
| Date Deposited: | 12 Dec 2011 16:51 |
| Last Modified: | 30 Sep 2014 15:27 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22853 |
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