The role of RNA interference in heterochromatic silencing

Lippman, Z., Martienssen, R. A. (2004) The role of RNA interference in heterochromatic silencing. Nature, 431 (7006). pp. 364-70. ISSN 1476-4687 (Electronic)

URL: http://www.ncbi.nlm.nih.gov/pubmed/15372044
DOI: 10.1038/nature02875

Abstract

Soon after its discovery 75 years ago, heterochromatin, a dense chromosomal material, was found to silence genes. But its importance in regulating gene expression was controversial. Long thought to be inert, heterochromatin is now known to give rise to small RNAs, which, by means of RNA interference, direct the modification of proteins and DNA in heterochromatic repeats and transposable elements. Heterochromatin has thus emerged as a key factor in epigenetic regulation of gene expression, chromosome behaviour and evolution.

Item Type: Paper
Uncontrolled Keywords: Animals Gene Expression Regulation Plant Genomic Imprinting genetics Heterochromatin genetics metabolism RNA Interference physiology Repetitive Sequences Nucleic Acid genetics Yeasts genetics
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene silencing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics > heterochromatin
CSHL Authors:
Communities: CSHL labs > Lippman lab
CSHL labs > Martienssen lab
Watson School > Publications
Depositing User: CSHL Librarian
Date Deposited: 31 Jan 2012 20:06
Last Modified: 19 Sep 2014 15:02
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22425

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