Precise development of functional and anatomical columns in the neocortex

Bureau, I., Shepherd, G. M., Svoboda, K. (June 2004) Precise development of functional and anatomical columns in the neocortex. Neuron, 42 (5). pp. 789-801. ISSN 0896-6273 (Print)

DOI: 10.1016/j.neuron.2004.05.002

Abstract

Sensory cortex is ordered into columns, each tuned to a subset of peripheral stimuli. To identify the principles underlying the construction of columnar architecture, we monitored the development of circuits in the rat barrel cortex, using laser-scanning photostimulation analysis of synaptic connectivity, reconstructions of axonal arbors, and in vivo whole-cell recording. Circuits impinging onto layer 2/3 neurons from layers 4 and 2/3 developed in a monotonic, precise progression, with little evidence for transient hyperinnervation at the level of cortical columns. Consistent with this, synaptic currents measured in layer 2/3 neurons at PND 8, just after these neurons ceased to migrate, revealed already spatially well-tuned receptive fields.

Item Type: Paper
Uncontrolled Keywords: Action Potentials physiology radiation effects Age Factors Animals Animals Newborn Axons metabolism Brain Mapping Dendrites metabolism Electric Stimulation Lasers Membrane Potentials Neocortex anatomy & histology cytology growth & development physiology Nerve Net cytology physiology Neurons classification physiology Patch-Clamp Techniques Photic Stimulation instrumentation methods Rats Rats Sprague-Dawley Reaction Time Synapses classification physiology Vibrissae innervation physiology
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > barrel cortex
CSHL Authors:
Depositing User: CSHL Librarian
Date: 10 June 2004
Date Deposited: 14 Feb 2012 17:15
Last Modified: 14 Feb 2012 17:15
URI: http://repository.cshl.edu/id/eprint/22335

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