Bureau, I., Shepherd, G. M., Svoboda, K. (June 2004) Precise development of functional and anatomical columns in the neocortex. Neuron, 42 (5). pp. 789-801. ISSN 0896-6273 (Print)
Abstract
Sensory cortex is ordered into columns, each tuned to a subset of peripheral stimuli. To identify the principles underlying the construction of columnar architecture, we monitored the development of circuits in the rat barrel cortex, using laser-scanning photostimulation analysis of synaptic connectivity, reconstructions of axonal arbors, and in vivo whole-cell recording. Circuits impinging onto layer 2/3 neurons from layers 4 and 2/3 developed in a monotonic, precise progression, with little evidence for transient hyperinnervation at the level of cortical columns. Consistent with this, synaptic currents measured in layer 2/3 neurons at PND 8, just after these neurons ceased to migrate, revealed already spatially well-tuned receptive fields.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Action Potentials physiology radiation effects Age Factors Animals Animals Newborn Axons metabolism Brain Mapping Dendrites metabolism Electric Stimulation Lasers Membrane Potentials Neocortex anatomy & histology cytology growth & development physiology Nerve Net cytology physiology Neurons classification physiology Patch-Clamp Techniques Photic Stimulation instrumentation methods Rats Rats Sprague-Dawley Reaction Time Synapses classification physiology Vibrissae innervation physiology |
| Subjects: | organs, tissues, organelles, cell types and functions > tissues types and functions > barrel cortex |
| CSHL Authors: | |
| Depositing User: | CSHL Librarian |
| Date: | 10 June 2004 |
| Date Deposited: | 14 Feb 2012 17:15 |
| Last Modified: | 14 Feb 2012 17:15 |
| URI: | https://repository.cshl.edu/id/eprint/22335 |
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