Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

Encinas, J. M., Michurina, T. V., Peunova, N., Park, J.H., Tordo, J., Peterson, D. A., Fishell, G., Koulakov, A. A., Enikolopov, G. N. (2011) Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus. Cell Stem Cell, 8 (5). pp. 566-579. ISSN 1934-5909

URL: http://www.ncbi.nlm.nih.gov/pubmed/21549330
DOI: 10.1016/j.stem.2011.03.010

Abstract

Summary Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment. Here we show that continuous depletion of the neural stem cell pool, as a consequence of their division, may contribute to the age-related decrease in hippocampal neurogenesis. Our results indicate that adult hippocampal stem cells, upon exiting their quiescent state, rapidly undergo a series of asymmetric divisions to produce dividing progeny destined to become neurons and subsequently convert into mature astrocytes. Thus, the decrease in the number of neural stem cells is a division-coupled process and is directly related to their production of new neurons. We present a scheme of the neurogenesis cascade in the adult hippocampus that includes a proposed "disposable stem cell" model and accounts for the disappearance of hippocampal neural stem cells, the appearance of new astrocytes, and the age-related decline in the production of new neurons.

Item Type: Paper
Subjects: organism description > animal > developmental stage > adult
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
therapies > stem cells
CSHL Authors:
Communities: CSHL Cancer Center Shared Resources > Animal Services
CSHL Cancer Center Shared Resources > Microscopy Service
CSHL Post Doctoral Fellows
CSHL labs > Enikopolov lab
CSHL labs > Koulakov lab
CSHL Cancer Center Program > Signal Transduction
Depositing User: CSHL Librarian
Date Deposited: 09 Nov 2011 16:15
Last Modified: 15 Oct 2015 20:04
PMCID: PMC3286186
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15628

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