Encinas, J. M., Michurina, T. V., Peunova, N., Park, J.H., Tordo, J., Peterson, D. A., Fishell, G., Koulakov, A. A., Enikolopov, G. N. (May 2011) Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus. Cell Stem Cell, 8 (5). pp. 566-579. ISSN 1934-5909
Abstract
Summary Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment. Here we show that continuous depletion of the neural stem cell pool, as a consequence of their division, may contribute to the age-related decrease in hippocampal neurogenesis. Our results indicate that adult hippocampal stem cells, upon exiting their quiescent state, rapidly undergo a series of asymmetric divisions to produce dividing progeny destined to become neurons and subsequently convert into mature astrocytes. Thus, the decrease in the number of neural stem cells is a division-coupled process and is directly related to their production of new neurons. We present a scheme of the neurogenesis cascade in the adult hippocampus that includes a proposed "disposable stem cell" model and accounts for the disappearance of hippocampal neural stem cells, the appearance of new astrocytes, and the age-related decline in the production of new neurons.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal > developmental stage > adult organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus therapies > stem cells |
| CSHL Authors: | |
| Communities: | CSHL Cancer Center Shared Resources > Animal Services CSHL Cancer Center Shared Resources > Microscopy Service CSHL Post Doctoral Fellows CSHL labs > Enikopolov lab CSHL labs > Koulakov lab CSHL Cancer Center Program > Signal Transduction |
| Depositing User: | CSHL Librarian |
| Date: | May 2011 |
| Date Deposited: | 09 Nov 2011 16:15 |
| Last Modified: | 15 Oct 2015 20:04 |
| PMCID: | PMC3286186 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/15628 |
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