Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

Mills, A. A. (2010) Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer, 10 (10). pp. 669-82. ISSN 1474-1768 (Electronic) 1474-175X (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/20865010
DOI: 10.1038/nrc2931

Abstract

The discovery that cancer can be governed above and beyond the level of our DNA presents a new era for designing therapies that reverse the epigenetic state of a tumour cell. Understanding how altered chromatin dynamics leads to malignancy is essential for controlling tumour cells while sparing normal cells. Polycomb and trithorax group proteins are evolutionarily conserved and maintain chromatin in the 'off' or 'on' states, thereby preventing or promoting gene expression, respectively. Recent work highlights the dynamic interplay between these opposing classes of proteins, providing new avenues for understanding how these epigenetic regulators function in tumorigenesis.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: CSHL Librarian
Date Deposited: 03 Oct 2011 15:45
Last Modified: 02 Feb 2017 16:49
PMCID: PMC4068012
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15482

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