Mills, A. A. (October 2010) Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer, 10 (10). pp. 669-82. ISSN 1474-1768 (Electronic) 1474-175X (Linking)
Abstract
The discovery that cancer can be governed above and beyond the level of our DNA presents a new era for designing therapies that reverse the epigenetic state of a tumour cell. Understanding how altered chromatin dynamics leads to malignancy is essential for controlling tumour cells while sparing normal cells. Polycomb and trithorax group proteins are evolutionarily conserved and maintain chromatin in the 'off' or 'on' states, thereby preventing or promoting gene expression, respectively. Recent work highlights the dynamic interplay between these opposing classes of proteins, providing new avenues for understanding how these epigenetic regulators function in tumorigenesis.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics |
| CSHL Authors: | |
| Communities: | CSHL labs > Mills lab |
| Depositing User: | CSHL Librarian |
| Date: | October 2010 |
| Date Deposited: | 03 Oct 2011 15:45 |
| Last Modified: | 02 Feb 2017 16:49 |
| PMCID: | PMC4068012 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/15482 |
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