Tumors as Organs: Complex Tissues that Interface with the Entire Organism

Egeblad, M., Nakasone, E. S., Werb, Z. (June 2010) Tumors as Organs: Complex Tissues that Interface with the Entire Organism. Developmental Cell, 18 (6). pp. 884-901. ISSN 1534-5807

URL: http://www.ncbi.nlm.nih.gov/pubmed/20627072
DOI: 10.1016/j.devcel.2010.05.012

Abstract

Solid tumors are not simply clones of cancer cells. Instead, they are abnormal organs composed of multiple cell types and extracellular matrix. Some aspects of tumor development resemble processes seen in developing organs, whereas others are more akin to tissue remodeling. Some microenvironments, particularly those associated with tissue injury, are favorable for progression of mutant cells, whereas others restrict it. Cancer cells can also instruct surrounding tissues to undergo changes that promote malignancy. Understanding the complex ways in which cancer cells interact with their surroundings, both locally in the tumor organ and systemically in the body as a whole, has implications for effective cancer prevention and therapy.

Item Type: Paper
Uncontrolled Keywords: EPITHELIAL-MESENCHYMAL TRANSITION BREAST-CANCER METASTASIS ROUS-SARCOMA VIRUS CD4(+) T-CELLS NF-KAPPA-B BONE-MARROW STEM-CELLS TGF-BETA MOUSE MODEL IN-VIVO
Subjects: diseases & disorders > cancer > cancer types > breast cancer
organism description > animal > mammal > rodent > mouse
therapies > stem cells
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
CSHL Authors:
Communities: CSHL labs > Egeblad lab
Watson School > Publications
Depositing User: CSHL Librarian
Date: June 2010
Date Deposited: 29 Sep 2011 19:37
Last Modified: 22 Sep 2014 19:16
PMCID: PMC2905377
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15404

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