Items where Community is "Furukawa lab"

Polfer, Rachel, Furukawa, Hiro (October 2024) Biology, function and structure of the calcium homeostasis modulator family. Journal of Physiology. ISSN 0022-3751

Jain, Anant, Nakahata, Yoshihisa, Pancani, Tristano, Watabe, Tetsuya, Rusina, Polina, South, Kelly, Adachi, Kengo, Yan, Long, Simorowski, Noriko, Furukawa, Hiro, Yasuda, Ryohei (October 2024) Dendritic, delayed, stochastic CaMKII activation in behavioural time scale plasticity. Nature. ISSN 0028-0836 (Public Dataset)

Michalski, Kevin, Abdulla, Taha, Kleeman, Sam, Schmidl, Lars, Gómez, Ricardo, Simorowski, Noriko, Vallese, Francesca, Prüss, Harald, Heckmann, Manfred, Geis, Christian, Furukawa, Hiro (September 2024) Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis. Nature Structural & Molecular Biology. ISSN 1545-9993 (Public Dataset)

Chou, Tsung-Han, Epstein, Max, Fritzemeier, Russell G, Akins, Nicholas S, Paladugu, Srinu, Ullman, Elijah Z, Liotta, Dennis C, Traynelis, Stephen F, Furukawa, Hiro (August 2024) Molecular mechanism of ligand gating and opening of NMDA receptor. Nature, 632 (8023). pp. 209-217. ISSN 0028-0836 (Public Dataset)

Michalski, Kevin, Furukawa, Hiro (April 2024) Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel. Science Advances, 10 (15). eadl5952. ISSN 2375-2548

Jain, Anant, Nakahata, Yoshihisa, Watabe, Tetsuya, Rusina, Polina, South, Kelly, Adachi, Kengo, Yan, Long, Simorowski, Noriko, Furukawa, Hiro, Yasuda, Ryohei (August 2023) Dendritic, delayed, and stochastic CaMKII activation underlies behavioral time scale plasticity in CA1 synapses. (Submitted)

Syrjänen, Johanna L, Epstein, Max, Gómez, Ricardo, Furukawa, Hiro (June 2023) Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red. Nature Communications, 14 (1). p. 3821. ISSN 2041-1723 (Public Dataset)

Meze, Katarina, Axhemi, Armend, Thomas, Dennis R, Doymaz, Ahmet, Joshua-Tor, Leemor (February 2023) A shape-shifting nuclease unravels structured RNA. Nature Structural and Molecular Biology. ISSN 1545-9993 (Public Dataset)

Harris, Lynnea D, Regan, Michael C, Myers, Scott J, Nocilla, Kelsey A, Akins, Nicholas S, Tahirovic, Yesim A, Wilson, Lawrence J, Dingledine, Ray, Furukawa, Hiro, Traynelis, Stephen F, Liotta, Dennis C (February 2023) Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model. ACS Chemical Neuroscience. ISSN 1948-7193

Yovanno, Remy A, Chou, Tsung Han, Brantley, Sarah J, Furukawa, Hiro, Lau, Albert Y (October 2022) Excitatory and inhibitory D-serine binding to the NMDA receptor. eLife, 11. e77645. ISSN 2050-084X

Chou, Tsung-Han, Kang, Hyunook, Simorowski, Noriko, Traynelis, Stephen F, Furukawa, Hiro (October 2022) Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Molecular Cell. S1097-2765(22)00965. ISSN 1097-2765

Steigerwald, Ruben, Chou, Tsung-Han, Furukawa, Hiro, Wünsch, Bernhard (September 2022) GluN2A-selective NMDA receptor antagonists: Mimicking the U-shaped bioactive conformation of TCN-201 by a [2.2]paracyclophane system. ChemMedChem: chemistry enabling drug discovery. ISSN 1860-7179

Chou, Tsung-Han, Epstein, Max, Michalski, Kevin, Fine, Eve, Biggin, Philip C, Furukawa, Hiro (May 2022) Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nature Structural and Molecular Biology. ISSN 1545-9993

Tajima, Nami, Simorowski, Noriko, Yovanno, Remy A, Regan, Michael C, Michalski, Kevin, Gómez, Ricardo, Lau, Albert Y, Furukawa, Hiro (February 2022) Development and characterization of functional antibodies targeting NMDA receptors. Nature Communications, 13 (1). p. 923. ISSN 2041-1723

Yovanno, Remy, Chou, Tsung Han, Brantley, Sarah, Furukawa, Hiro, Lau, Albert (2022) Excitatory and inhibitory D-serine binding to the NMDA receptor. bioRxiv. (Submitted)

Meze, Katarina, Axhemi, Armend, Thomas, Dennis, Joshua-Tor, Leemor (October 2021) The 3 '-5 ' Exonuclease Dis3L2 Undergoes Conformational Dynamics During Structured RNA Degradation. In: Protein Science 35th Anniversary Symposium.

Hansen, Kasper B, Wollmuth, Lonnie P, Bowie, Derek, Furukawa, Hiro, Menniti, Frank S, Sobolevsky, Alexander I, Swanson, Geoffrey T, Swanger, Sharon A, Greger, Ingo H, Nakagawa, Terunaga, McBain, Chris J, Jayaraman, Vasanthi, Low, Chian-Ming, Dell'Acqua, Mark L, Diamond, Jeffrey S, Camp, Chad R, Perszyk, Riley E, Yuan, Hongjie, Traynelis, Stephen F (October 2021) Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacological Reviews, 73 (4). pp. 298-487. ISSN 0031-6997

Syrjanen, Johanna, Michalski, Kevin, Kawate, Toshimitsu, Furukawa, Hiro (April 2021) On the molecular nature of large-pore channels. Journal of Molecular Biology. p. 166994. ISSN 0022-2836

Syrjanen, Johanna L, Michalski, Kevin, Chou, Tsung-Han, Rao, Shanlin, Henze, Eric, Kumpf, Julia M, Simorowski, Noriko, Grant, Tim, Grigorieff, Nikolaus, Tucker, Stephen J, Kawate, Toshimitsu, Furukawa, Hiro (February 2021) Exploring the Three-Dimensional Architectures of Two Families of Large Pore Channels (CALHM1,2 and Pannexin1). In: Biophysical Society Annual Meeting.

Chou, Tsung-Han, Tajima, Nami, Romero-Hernandez, Annabel, Furukawa, Hiro (February 2021) Structural Basis of Functional Transitions in Mammalian NMDA Receptors. In: Biophysical Society Annual Meeting.

Furukawa, H, Simorowski, N, Michalski, K (January 2021) Effective production of oligomeric membrane proteins by EarlyBac-insect cell system. In: Methods in Enzymology. Elsevier.

Meze, Katarina, Axhemi, Armend, Thomas, Dennis, Doymaz, Ahmet, Joshua-Tor, Leemor (2021) A shape-shifting nuclease unravels structured RNA. bioRxiv. (Submitted)

Perszyk, R. E., Myers, S. J., Yuan, H., Gibb, A. J., Furukawa, H., Sobolevsky, A. I., Traynelis, S. F. (August 2020) Hodgkin-Huxley-Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif. J Physiol, 598 (15). pp. 3071-3083. ISSN 0022-3751

Chou, Tsung-Han, Tajima, Nami, Romero-Hernandez, Annabel, Furukawa, Hiro (July 2020) Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182 (2). 357-371.e13. ISSN 0092-8674

Syrjanen, Johanna L, Michalski, Kevin, Chou, Tsung-Han, Grant, Timothy, Rao, Shanlin, Simorowski, Noriko, Tucker, Stephen J, Grigorieff, Nikolaus, Furukawa, Hiro (March 2020) Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins. Nature Structural and Molecular Biology, 27 (3). p. 305. ISSN 1545-9993

Michalski, K., Syrjanen, J. L., Henze, E., Kumpf, J., Furukawa, H., Kawate, T. (February 2020) The cryo-EM structure of a pannexin 1 reveals unique motifs for ion selection and inhibition. Elife, 9. ISSN 2050-084x

Syrjanen, J. L., Michalski, K., Chou, T. H., Grant, T., Rao, S., Simorowski, N., Tucker, S. J., Grigorieff, N., Furukawa, H. (January 2020) Structure and assembly of calcium homeostasis modulator proteins. Nat Struct Mol Biol, 27 (2). pp. 150-159. ISSN 1545-9985 (Public Dataset)

Wang, J. X., Irvine, M. W., Burnell, E. S., Sapkota, K., Thatcher, R. J., Li, M., Simorowski, N., Volianskis, A., Collingridge, G. L., Monaghan, D. T., Jane, D. E., Furukawa, H. (January 2020) Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors. Nat Commun, 11 (1). p. 423. ISSN 2041-1723 (Public Dataset)

Wang, J. X., Furukawa, H. (January 2019) Dissecting diverse functions of NMDA receptors by structural biology. Curr Opin Struct Biol, 54. pp. 34-42. ISSN 0959-440x

Regan, M. C., Zhu, Z., Yuan, H., Myers, S. J., Menaldino, D. S., Tahirovic, Y. A., Liotta, D. C., Traynelis, S. F., Furukawa, H. (January 2019) Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors. Nat Commun, 10 (1). p. 321. ISSN 2041-1723

Syrjanen, Johanna, Michalski, Kevin, Chou, Tsung-Han, Grant, Timothy, Rao, Shanlin, Simorowski, Noriko, Tucker, Stephen, Grigorieff, Nikolaus, Furukawa, Hiro (2019) Structure and assembly of calcium homeostasis modulator proteins. Nature Structural and Molecular Biology. (Submitted)

Hansen, K. B., Yi, F., Perszyk, R. E., Furukawa, H., Wollmuth, L. P., Gibb, A. J., Traynelis, S. F. (July 2018) Structure, function, and allosteric modulation of NMDA receptors. J Gen Physiol. ISSN 0022-1295

Regan, M. C., Grant, T., McDaniel, M. J., Karakas, E., Zhang, J., Traynelis, S. F., Grigorieff, N., Furukawa, H. (May 2018) Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors. Neuron, 98 (3). pp. 521-529. ISSN 0896-6273

Wu, Q., Regan, M., Furukawa, H., Jackson, D. (April 2018) Role of heterotrimeric Galpha proteins in maize development and enhancement of agronomic traits. PLoS Genet, 14 (4). e1007374. ISSN 1553-7390

Tajima, Nami (February 2018) Molecular Mechanisms of NMDA Receptor Function and Regulation. Biophysical Journal, 114 (3, Sup). 25a. ISSN 0006-3495

Elegheert, Jonathan, Cvetkovska, Vedrana, Clayton, Amber J, Heroven, Christina, Vennekens, Kristel M, Smukowski, Samuel N, Regan, Michael C, Jia, Wanyi, Smith, Alexandra C, Furukawa, Hiro, Savas, Jeffrey N, de Wit, Joris, Begbie, Jo, Craig, Ann Marie, Aricescu, A Radu (September 2017) Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron, 96 (1). pp. 242-244. ISSN 0896-6273

Elegheert, Jonathan, Cvetkovska, Vedrana, Clayton, Amber J., Heroven, Christina, Vennekens, Kristel M., Smukowski, Samuel N., Regan, Michael C., Jia, Wanyi, Smith, Alexandra C., Furukawa, Hiro, Savas, Jeffrey N., de Wit, Joris, Begbie, Jo, Craig, Ann Marie, Aricescu, A. Radu (August 2017) Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron, 95 (4). 896-913.e10. ISSN 0896-6273 (Public Dataset)

Furukawa, H (August 2017) Structure and pharmacology of NMDA receptors. In: ISN-ESN Meeting.

Romero-Hernandez, A., Furukawa, H. (July 2017) Novel mode of antagonist binding in NMDA receptors revealed by the crystal structure of the GluN1-GluN2A ligand-binding domain complexed to NVP-AAM077. Mol Pharmacol, 92 (1). pp. 22-29. ISSN 0026-895x (Public Dataset)

Amin, J. B., Salussolia, C. L., Chan, K., Regan, M. C., Dai, J., Zhou, H. X., Furukawa, H., Bowen, M. E., Wollmuth, L. P. (June 2017) Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors. J Gen Physiol, 149 (6). pp. 661-680. ISSN 0022-1295

Romero-Hernandez, Annabel, Simorowski, Noriko, Karakas, Erkan, Furukawa, Hiro (December 2016) Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain. Neuron, 92 (6). pp. 1324-1336. ISSN 0896-6273 (Public Dataset)

Regan, Michael C., Furukawa, Hiro (September 2016) Deeper Insights into the Allosteric Modulation of Ionotropic Glutamate Receptors. Neuron, 91 (6). pp. 1187-1189. ISSN 0896-6273

Malinauskas, Tomas, Furukawa, Hiro (June 2016) Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry. Structure, 24 (6). pp. 1008-1009. ISSN 0969-2126

Malinauskas, Tomas, Furukawa, Hiro (May 2016) Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry. Structure, 24 (5). pp. 653-655. ISSN 0969-2126

Tajima, N., Karakas, E., Grant, T., Simorowski, N., Diaz-Avalos, R., Grigorieff, N., Furukawa, H. (May 2016) Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Nature, 534 (7605). pp. 63-8. ISSN 1476-4687 (Electronic)0028-0836 (Linking) (Public Dataset)

Cai, Na, Li, Yihan, Chang, Simon, Liang, Jieqin, Lin, Chongyun, Zhang, Xiufei, Liang, Lu, Hu, Jingchu, Chan, Wharton, Kendler, Kenneth S, Malinauskas, Tomas, Huang, Guo-Jen, Li, Qibin, Mott, Richard, Flint, Jonathan (December 2015) Genetic Control over mtDNA and Its Relationship to Major Depressive Disorder. Current Biology, 25 (24). pp. 3170-3177. ISSN 0960-9822

Regan, Michael C., Romero-Hernandez, Annabel, Furukawa, Hiro (August 2015) A structural biology perspective on NMDA receptor pharmacology and function. Current Opinion in Structural Biology, 33. pp. 68-75. ISSN 0959-440X

van Schouwenburg, Pauline A., Davenport, Emma E., Kienzler, Anne-Kathrin, Marwah, Ishita, Wright, Benjamin, Lucas, Mary, Malinauskas, Tomas, Martin, Hilary C., Lockstone, Helen E., Cazier, Jean-Baptiste, Chapel, Helen M., Knight, Julian C., Patel, Smita Y. (June 2015) Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency. Clinical Immunology, 160 (2). pp. 301-314. ISSN 1521-6616

Karakas, Erkan, Regan, Michael C., Furukawa, Hiro (June 2015) Emerging structural insights into the function of ionotropic glutamate receptors. Trends in Biochemical Sciences, 40 (6). pp. 328-337. ISSN 0968-0004

Bauza, K., Atcheson, E., Malinauskas, T., Blagborough, A. M., Reyes-Sandoval, A. (March 2015) Tailoring a Combination Preerythrocytic Malaria Vaccine. Infect Immun, 84 (3). pp. 622-34. ISSN 1098-5522 (Electronic)0019-9567 (Linking)

Malinauskas, Tomas, Jones, E. Yvonne (December 2014) Extracellular modulators of Wnt signalling. Current Opinion in Structural Biology, 29. pp. 77-84. ISSN 0959-440X

Khatri, A., Burger, P. B., Swanger, S. A., Hansen, K. B., Zimmerman, S., Karakas, E., Liotta, D. C., Furukawa, H., Snyder, J. P., Traynelis, S. F. (September 2014) Structural Determinants and Mechanism of Action of a GluN2C-selective NMDA Receptor Positive Allosteric Modulator. Mol Pharmacol, 86 (5). pp. 548-560. ISSN 0026-895x

Karakas, E., Furukawa, H. (May 2014) Crystal structure of a heterotetrameric NMDA receptor ion channel. Science, 344 (6187). pp. 992-7. ISSN 1095-9203 (Electronic)0036-8075 (Linking) (Public Dataset)

Hiro Furukawa (February 2014) Phenylethanolamine-based NMDA receptor antagonists. United States Patent 8648198. .

Jespersen, A., Tajima, N., Fernandez-Cuervo, G., Garnier-Amblard, E. C., Furukawa, H. (January 2014) Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81 (2). pp. 366-78. ISSN 0896-6273 (Public Dataset)

Hansen, K. B., Tajima, N., Risgaard, R., Perszyk, R. E., Jorgensen, L., Vance, K. M., Ogden, K. K., Clausen, R. P., Furukawa, H., Traynelis, S. F. (July 2013) Structural determinants of agonist efficacy at the glutamate binding site of n-methyl-d-Aspartate receptorss. Molecular Pharmacology, 84 (1). pp. 114-127. ISSN 0026895X (Public Dataset)

Salussolia, C. L., Gan, Q., Kazi, R., Singh, P., Allopenna, J., Furukawa, H., Wollmuth, L. P. (June 2013) A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors. Journal of Neuroscience, 33 (23). pp. 9840-9845. ISSN 02706474

Burger, P. B., Yuan, H. J., Karakas, E., Geballe, M., Furukawa, H., Liotta, D. C., Snyder, J. P., Traynelis, S. F. (August 2012) Mapping the Binding of GluN2B-Selective N-Methyl-D-aspartate Receptor Negative Allosteric Modulators. Molecular Pharmacology, 82 (2). pp. 344-359. ISSN 0026-895X

Furukawa, H. (February 2012) Structure and function of glutamate receptor amino terminal domains. Journal of Physiology, 590 (1). pp. 63-72. ISSN 00223751 (ISSN)

Furukawa, Hiro (January 2012) Structural Dissection of NMDA Receptor Pharmacology. In: 56th Annual Meeting of the Biophysical-Society.

Furukawa, H. (November 2011) Talk from Hiro Furukawa at the Cold Spring Harbor Laboratory In-House Symposium (2011). [Video] (Unpublished)

Karakas, E., Simorowski, N., Furukawa, H. (July 2011) Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Nature, 475 (7355). 249- U170. ISSN 00280836 (Public Dataset)

Vance, K. M., Simorowski, N., Traynelis, S. F., Furukawa, H. (April 2011) Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nature Communications, 2. ISSN 2041-1723 (Public Dataset)

Hansen, K. B., Furukawa, H., Traynelis, S. F. (October 2010) Control of Assembly and Function of Glutamate Receptors by the Amino-Terminal Domain. Molecular Pharmacology, 78 (4). pp. 535-549. ISSN 0026-895X

Boguth, C. A., Singh, Puja, Huang, C. C., Tesmer, J. J. G. (August 2010) Molecular basis for activation of G protein-coupled receptor kinases. EMBO Journal, 29 (19). pp. 3249-3259.

Karakas, Erkan, Simorowski, Noriko, Furukawa, Hiro (January 2010) Structural Insights into Allosteric Modulation of NMDA Receptors Through the Amino-Terminal Domain. Biophysical Journal, 98 (3, Sup). 609a-609a.

Karakas, E., Simorowski, N., Furukawa, H. (November 2009) Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. Embo Journal, 28 (24). pp. 3910-3920. ISSN 0261-4189 (Public Dataset)

Jin, R., Singh, S. K., Gu, S., Furukawa, H., Sobolevsky, A. I., Zhou, J., Jin, Y., Gouaux, E. (June 2009) Crystal structure and association behaviour of the GluR2 amino-terminal domain. Embo J, 28 (12). pp. 1812-23. ISSN 1460-2075 (Electronic)1460-2075 (Linking) (Public Dataset)

Jasti, J., Furukawa, H., Gonzales, E. B., Gouaux, E. (September 2007) Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature, 449 (7160). pp. 316-23. ISSN 1476-4687 (Electronic) 1476-4687 (Linking) (Public Dataset)

Vasquez, V., Cortes, D. M., Furukawa, H., Perozo, E. (June 2007) An optimized purification and reconstitution method for the MscS channel: strategies for spectroscopical analysis. Biochemistry, 46 (23). pp. 6766-73. ISSN 0006-2960 (Print)0006-2960 (Linking)

Takahashi, H., Shin, Y., Cho, S. J., Zago, W. M., Nakamura, T., Gu, Z., Ma, Y., Furukawa, H., Liddington, R., Zhang, D., Tong, G., Chen, H. S., Lipton, S. A. (January 2007) Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif. Neuron, 53 (1). pp. 53-64. ISSN 0896-6273 (Print)0896-6273 (Linking)

Furukawa, H., Singh, S. K., Mancusso, R., Gouaux, E. (November 2005) Subunit arrangement and function in NMDA receptors. Nature, 438 (7065). pp. 185-192. ISSN 0028-08361476-4687 (Electronic)1476-4687 (Linking) (Public Dataset)

Inanobe, A., Furukawa, H., Gouaux, E. (July 2005) Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron, 47 (1). pp. 71-84. ISSN 0896-6273 (Print)0896-6273 (Linking) (Public Dataset)

Furukawa, H, Hamada, T, Ishiguro, M, Hirota, H, Haga, T (2005) Determination of steric structure of muscarinic ligands bound to muscarinic receptors: approaches by TRNOE (transferred nuclear Overhauser effect). In: G protein-coupled receptors: structure, function, and ligand screening. CRC Press, pp. 261-281. ISBN 978-0-8493-2771-1

Furukawa, H., Gouaux, E. (June 2003) Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core. Embo J, 22 (12). pp. 2873-85. ISSN 0261-4189 (Print)0261-4189 (Linking) (Public Dataset)

Furukawa, H., Hamada, T., Hayashi, M. K., Haga, T., Muto, Y., Hirota, H., Yokoyama, S., Nagasawa, K., Ishiguro, M. (October 2002) Conformation of ligands bound to the muscarinic acetylcholine receptor. Mol Pharmacol, 62 (4). pp. 778-87. ISSN 0026-895X (Print)0026-895X (Linking)

Furukawa, H., Haga, T. (January 2000) Expression of functional M2 muscarinic acetylcholine receptor in Escherichia coli. J Biochem, 127 (1). pp. 151-61. ISSN 0021-924X (Print)