On the molecular nature of large-pore channels.

Syrjanen, Johanna, Michalski, Kevin, Kawate, Toshimitsu, Furukawa, Hiro (April 2021) On the molecular nature of large-pore channels. Journal of Molecular Biology. p. 166994. ISSN 0022-2836

URL: https://www.ncbi.nlm.nih.gov/pubmed/33865869
DOI: 10.1016/j.jmb.2021.166994


Membrane transport is a fundamental means to control basic cellular processes such as apoptosis, inflammation, and neurodegeneration and is mediated by a number of transporters, pumps, and channels. Accumulating evidence over the last half century has shown that a type of so-called "large-pore channel" exists in various tissues and organs in gap-junctional and non-gap-junctional forms in order to flow not only ions but also metabolites such as ATP. They are formed by a number of protein families with little or no evolutionary linkages including connexin, innexin, pannexin, leucine-rich repeat-containing 8 (LRRC8), and calcium homeostasis modulator (CALHM). This review summarizes the history and concept of large-pore channels starting from connexin gap junction channels to the more recent developments in innexin, pannexin, LRRC8, and CALHM. We describe structural and functional features of large-pore channels that are crucial for their diverse functions on the basis of available structures.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > ion channel
Publication Type > review
CSHL Authors:
Communities: CSHL labs > Furukawa lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 15 April 2021
Date Deposited: 04 May 2021 14:16
Last Modified: 07 Sep 2021 13:13
PMCID: PMC8409005
Related URLs:
URI: https://repository.cshl.edu/id/eprint/39978

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