Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice

Bureau, I., Shepherd, G. M., Svoboda, K. (May 2008) Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice. J Neurosci, 28 (20). pp. 5178-88.

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DOI: 10.1523/JNEUROSCI.1076-08.2008


Silencing of the Fmr1 gene causes fragile X syndrome. Although defects in synaptic plasticity in the cerebral cortex have been linked to cognitive impairments in Fmr1 knock-out (ko) mice, the specific cortical circuits affected in the syndrome are unknown. Here, we investigated the development of excitatory projections in the barrel cortex of Fmr1 ko mice. In 2-week-old Fmr1 ko mice, a major ascending projection connecting layer 4 (L4) to L3 (L4-->L3), was defective in multiple and independent ways: its strength was reduced, caused by a lower connection probability; the axonal arbors of L4 cells were spatially diffuse in L2/3; the L4-->L3 projection did not show experience-dependent plasticity. By 3 weeks, the strength of the L4-->L3 projection was similar to that of wild type. Our data indicate that Fmr1 shapes sensory cortical circuits during a developmental critical period.

Item Type: Paper
Additional Information: DOI 10.1523/JNEUROSCI.1076-08.2008 PMCID: PMC2696604
Subjects: diseases & disorders > mental disorders > delirium dementia cognitive disorders
organism description > animal > mammal > rodent > mouse
CSHL Authors:
Communities: CSHL labs > Svoboda lab
Depositing User: Tom Adams
Date: 14 May 2008
Date Deposited: 25 Aug 2011 21:43
Last Modified: 06 Nov 2017 21:01
PMCID: PMC2696604
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