Bureau, I., Shepherd, G. M., Svoboda, K. (May 2008) Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice. J Neurosci, 28 (20). pp. 5178-88.
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Abstract
Silencing of the Fmr1 gene causes fragile X syndrome. Although defects in synaptic plasticity in the cerebral cortex have been linked to cognitive impairments in Fmr1 knock-out (ko) mice, the specific cortical circuits affected in the syndrome are unknown. Here, we investigated the development of excitatory projections in the barrel cortex of Fmr1 ko mice. In 2-week-old Fmr1 ko mice, a major ascending projection connecting layer 4 (L4) to L3 (L4-->L3), was defective in multiple and independent ways: its strength was reduced, caused by a lower connection probability; the axonal arbors of L4 cells were spatially diffuse in L2/3; the L4-->L3 projection did not show experience-dependent plasticity. By 3 weeks, the strength of the L4-->L3 projection was similar to that of wild type. Our data indicate that Fmr1 shapes sensory cortical circuits during a developmental critical period.
| Item Type: | Paper |
|---|---|
| Additional Information: | DOI 10.1523/JNEUROSCI.1076-08.2008 PMCID: PMC2696604 |
| Subjects: | diseases & disorders > mental disorders > delirium dementia cognitive disorders organism description > animal > mammal > rodent > mouse |
| CSHL Authors: | |
| Communities: | CSHL labs > Svoboda lab |
| Depositing User: | Tom Adams |
| Date: | 14 May 2008 |
| Date Deposited: | 25 Aug 2011 21:43 |
| Last Modified: | 06 Nov 2017 21:01 |
| PMCID: | PMC2696604 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/7695 |
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