Boyd, L, Borniger, JC (October 2025) Hypothalamic and physiological regulation of sleep in cancer. In: Sleep and Cancer. UNSPECIFIED, pp. 19-48. ISBN 9780443289385
Abstract
Sleep disruption is a common but poorly understood phenomenon in many different types of cancer. Here, we discuss putative molecular and neural circuit mechanisms driving disrupted sleep in the context of cancer, focusing on immune and metabolic signals arriving to the brain from the periphery. Most of these signals (e.g., glucose and cytokines) are disrupted during the course of cancer progression as tumors hijack host physiology to evade immune destruction and meet high energy demands. These metabolic and immune signals can independently impact host physiology but also engage in complex interactions, for example, the energetic demands of mounting an immune response, to create even more extreme burdens on the host. Many neuronal populations that control arousal states, and specifically those in the hypothalamus, are highly sensitive to these cues. Therefore cancer-induced changes in host physiology can independently drive sleep disruption via aberrant activation of arousal-regulating neurons in the brain. In this chapter, we highlight ongoing work disentangling the bidirectional communication between the brain and peripheral cancer and propose new avenues for exploration in basic and clinical research. Further understanding these pathways will provide a critical approach towards combating sleep disruption in patients with, and survivors of, cancer.
| Item Type: | Book Section |
|---|---|
| Subjects: | organism description > animal behavior > REM sleep organism description > animal behavior |
| CSHL Authors: | |
| Communities: | CSHL labs > Borniger lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 17 October 2025 |
| Date Deposited: | 06 Jan 2026 14:35 |
| Last Modified: | 06 Jan 2026 14:35 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/42062 |
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