Genetic determinants of gene expression noise and its role in complex trait variation

Long, Yuexuan, Ni, Xiaolin, Chen, Tingwei, Huang, Xianzhe, Hong, Qiyang, Wang, Jixin, Wang, Cong, Huang, Zigeng, Xu, Haiqing, Sun, Mengyi, Pang, Junling, Choi, Jiyeon, Zhang, Tongwu, Long, Erping (November 2025) Genetic determinants of gene expression noise and its role in complex trait variation. Cell Reports, 44 (12). p. 116612. ISSN 2211-1247

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Abstract

Even genetically identical cells in homogeneous environments exhibit heterogeneous mRNA abundance, typically called "gene expression noise," which is involved in key cellular activities, evolutionary processes, and disease mechanisms. However, determinants of the gene expression noise and its functional role in variations of human complex traits remain largely unexplored. Here, we established an atlas of gene expression noise from 1.23 million human peripheral blood cells of 981 individuals, identifying its age- and gender-dependent pattern. We then identified 10,770 independent expression noise quantitative trait loci (enQTLs) for 6,743 unique enGenes across seven immune cell types. Most enQTLs were distinct from expression quantitative trait loci (eQTLs) and showed differential enrichment of functional elements across the genome. Colocalization of enQTLs with trait-associated genetic loci interpreted previously unexplained loci. Overall, this study unravels the genetic determinants of gene expression noise and implicates as a previously underappreciated mechanism underlying variation of human complex traits and diseases.

Item Type: Paper
Subjects: bioinformatics
bioinformatics > genomics and proteomics
CSHL Authors:
Communities: CSHL labs > McCandlish lab
CSHL Post Doctoral Fellows
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 21 November 2025
Date Deposited: 01 Dec 2025 14:39
Last Modified: 01 Dec 2025 14:39
Related URLs:
URI: https://repository.cshl.edu/id/eprint/42019

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